Medicinal Chemistry Consulting
Fractional medicinal chemistry, from someone who has taken a molecule the distance.
Small-molecule drug discovery support for teams that need senior chemistry judgment without a full-time hire.
For heads of discovery at small biotechs
Experienced hands, scoped to the program
Fractional medicinal chemistry help when you need a senior read on hit assessment, SAR strategy, or lead optimization — sized to the program, not added to headcount.
For investors and boards
Independent chemistry diligence
An outside, experienced read on a portfolio company's discovery plan: the strength of the SAR story, the quality of the chemistry, and how close a program really is to a development candidate.
Track record
Specifics are kept general on purpose — programs, targets, and compounds are not named here.
- Co-inventor on issued patents in small-molecule discovery programs.
- First decade: formal hit assessments across multiple projects — from screening through hit declaration.
- Many subsequent years in lead optimization.
- One program carried personally from formal hit assessment through candidate selection. The resulting molecule successfully completed Phase 1 and is advancing toward Phase 2.
- Across the career: multiple programs at various stages of discovery, across multiple therapeutic areas.
What an engagement looks like
Every engagement is shaped around the program in front of us. Common starting points:
Hit assessment support
A structured read on screening output and hit series — what's real, what's tractable, what to prioritize.
SAR & design strategy
Working alongside the team on structure–activity direction, series selection, and design cycles.
Lead optimization guidance
Senior input on the multi-parameter push toward a candidate — potency, selectivity, properties, liabilities.
Chemistry diligence
An independent written assessment of a program's chemistry for a board, an investor, or a partnership decision.
Have a program that needs a senior chemistry read?
Tell me a little about where it stands. No program details required to start the conversation.